Hallmarks of Aging - 3
- Ersin Pamuksuzer

- Sep 15, 2025
- 3 min read
Dear Friends,
In the first article on the Hallmarks of Aging, we talked about our genetic heritage and the role of epigenetics in our lives. In the second, we explored the energy production of our cells and the importance of our stem cell reserves.
Today, we are going to look at some of the more silent, yet profoundly impactful, aspects of aging: the disruption of communication between cells, the slowing down of our intracellular cleansing processes, the silent progression of chronic inflammation and the destabilization of our microcosm in the gut.
Cells that don't hear each other, a body that neglects to cleanse itself, inflammation that constantly smolders like a smoldering fire and impaired gut flora... these issues are not our destiny as we age, but rather a clear call for support from our body:
"A simpler, more aware and more compassionate life is possible."
Weakened Communication Between Cells
In our body, cells are constantly talking; hormones, signals and molecules ensure this communication. Over time, this connection begins to weaken. Hormones fail to transmit messages; our nervous system only partially perceives impulses. Our immune system gets stuck in this disconnect and slows down.
So what can we do?
- We can strengthen our cell membranes by eating a diet rich in omega-3.
- By moving regularly, we can increase myokines, which enhance communication in the body.
Slowing of Intracellular Cleaning Systems (Autophagy)
Every cell has a cleaning system within it. This system recycles damaged proteins and old cell parts. However, as we age, this system slows down and waste starts to accumulate inside the cell.
So what can we do?
- We can activate the autophagy process through intermittent fasting.
- We can support cellular cleansing with foods like broccoli and green tea.
Persistent Low-Level Inflammation
With age, there is a constant low-level fire in the body. The immune system is constantly on alert, but it is unable to distinguish friend from foe. This slowly wears down our blood vessels, nerves and cell construction.
So what can we do?
- We can add natural anti-inflammatory foods such as omega-3, turmeric and ginger to our diet.
- We can lighten the burden of inflammation in our bodies by paying attention to weight control.
Disruption of the Balance of Intestinal Flora (Dysbiosis)
The community of microorganisms living in our intestines works in harmony with our body. As we age, this harmony is disrupted; harmful bacteria increase and beneficial ones decrease. As a result, the immune system weakens, digestion becomes more difficult and our mood can be negatively affected.
Let’s always remember the call of Hippocrates, which is more urgent in this age than ever –
“Let food be thy medicine and medicine be thy food.”
So where does this lead us, and what can we do?
- We can support beneficial bacteria by consuming prebiotic fibers such as onions, garlic and artichokes.
- We can strengthen gut health with probiotic foods such as organic yogurt, kefir and pickles.
- We can curb the growth of harmful bacteria with foods containing polyphenols such as green tea, cocoa and turmeric.
Conclusion:
These four topics give us a quiet but powerful message: Aging is inevitable, but how we age is in our hands. The decisions we make every day - what we eat, how we move, how we think - are the most important factors in determining how fast we age.
5 Easy Tips to Support Autophagy in Daily Life:
Intermittent Fasting: You can stimulate autophagy by not eating for 12-16 hours a day.
Consume Cruciferous Vegetables: You can support cellular cleansing with vegetables such as broccoli and cabbage.
Drink Green Tea: With EGCG you can stimulate natural autophagy.
Get Moving: Light walks or yoga stimulate the autophagy process.
Pay Attention to Sleep: Quality sleep is critical for cellular regeneration.
Small changes make big differences at the cellular level.
In the final article of this series, I will summarize all the points we have covered so far and offer practical suggestions to guide us in aging well.
Now, choose one small step today and give this message to your body:
"I hear you, I support you and we heal together."
Stay well and keep up the good work!


